Rocuronium bromide: a pharmacological study

This work was designed to assess the pharmacological effects of rocuronium. In either isolated preparation or intact animals. Rocuronium [6-96 micro g/ml] caused a significant dose related reduction in the amplitude of rat phrenic nerve diaphragm contraction in response to indirect stimulation, the mean percentage reduction were statistically significant. The addition of neostgmine [0.25 micro g/ml] caused complete reversal of the relaxant effect of rocuronium . In intact cat gastrocnemius sciatic nerve preparation rocuronium [25 - 200 micro g/kg] caused dose dependent statiscally significant reduction. In comparing the drug with succinyl choline by the head drop method the mean time in second was 15.34 +/-1.57 and 10.44 +/-0.91 respectively

Magnesium sulphate as a perioperative analgesic in pre-eclamptic parturients undergoing cesarean section

Magnesium sulphate has been used for many years in management of pre-eclampsia and eclampsia. Recently magnesium is known to have an antinociceptive value as a physiological calcium antagonist of N, methyl D, aspartate [NMDA] receptors also it inhibits catecholamine release from the adrenargic nerve terminals. We designed this work to assess the prioperative analgesia induced by MgSO[4] on twenty adult preeclamptic "mild cases" parturient, ASA physical status I, II undergoing elective cesarean section. First group [n=20] received a bolus of MgSO[4] 20% 50 mgkg[-1] diluted in 100 ml of I.V. fluid over 20 minutes, then infused at a rate of 0.5 gmh[-1] discontinued 24 hours postoperatively, Second group [n=20] received equal volumes of physiological saline general anaesthesia used, rapid sequence induction with the patients to be considered full stomach, guarding against traumatic manipulation to the oedematous tissue in the time of intubation and also when urinary catheter was applied standard monitors was used, Visual analogue scale was used which is a scale from 1-10 where [0=no paim and 10=worst pain] to assess the pain, total analgesic requirement was calculated, Neonatal general condition was evaluated by using Apgar scoring, arterial blood gas analysis. Our results showed that, the magnesium usage in pre eclamptic parturients resulted in more or less normalization of the blood pressure and heart rate of mothers, allowing a safe induction conditions no significant increase in means of blood pressure or heart rate, no any significant effects on the neonates, The analgesic requirement was reduced. To conclude that MgSO[4] is a good analgesic adjuvant can be used preoperatively with the desired haemodynamic stability and without any neonatal harmful side effects

Effect of rocuronium compared with succinylcholine on intraocular pressure during rapid sequence induction of anaesthesia

In this work, the effect of rocuronium and succinylcholine on IOP during rapid sequence induction of anesthesia using propofol and fentanyl were studied in 40 ASA grade I adult patients of both sexes who required tracheal intubation as a part of the anesthetic technique for elective non-ophthalmic surgery. The patients were divided into two groups, each of 20 patients. Anesthesia was induced by fentanyl mug/kg and a sleep dose of propofol until loss of verbal response. It was found that IOP in the succinylcholine group was significantly greater than that in the rocuronium group. Intubating conditions were equally good in both groups. The results confirmed that with a rapid sequence induction of anesthesia using propofol and fentanyl, rocuronium did not cause an increase in IOP and provided excellent to good intubating conditions in a dose of 0.9 mg/kg at 60 s after administration